Pendulum Akkermansia, Metabolic Daily, Glucose Control and GLP-1 Probiotic Review: It Runs Real Trials and Publishes Them — Then Markets a Result That Missed Statistical Significance
Pendulum is the most scientifically serious company in this entire review series. It was founded in 2013, is BBB accredited with an A+ rating, employs actual microbiologists, and — almost uniquely in supplements — has published its own randomised placebo-controlled trial in a peer-reviewed medical journal. That deserves real credit. It also markets Glucose Control as 'clinically shown to reduce A1C levels' on the basis of a trial where the A1c result came in at P = .054, which is not statistically significant. And it sells live Akkermansia, while the landmark human findings on Akkermansia came from the pasteurised form.
Read this first: This is a dietary supplement, not a medication. It is not FDA-approved to treat any condition, it is not a substitute for prescription GLP-1 medication such as semaglutide or tirzepatide, and nothing here should be read as a promise of weight loss. Supplements are regulated far more loosely than drugs. Talk to a healthcare professional who knows your history before starting anything, particularly if you take medication or have a medical condition.
Akkermansia
$54/mo on subscription · $75 one-time
Metabolic Daily
$49/mo · $69 one-time
GLP-1 Probiotic
$64/mo · $89 one-time
Glucose Control
$99–$267 · $139 one-time
Polyphenol Booster
$25–$75
Gut Fuel
$12–$108
Akkermansia potency
100M AFU per capsule
Company
Pendulum Therapeutics, Inc., San Francisco — since 2 January 2013
BBB
A+, accredited since 13 May 2022
Published trial
Perraudeau et al., BMJ Open Diab Res Care, 2020
Product Overview
Pendulum Therapeutics, Inc. operates from 933 20th Street, San Francisco, with a BBB start date of 2 January 2013. It is BBB accredited — and has been since 13 May 2022 — with an A+ rating. Thirteen years of trading and four years of accreditation is a solid record, and it is not a marketing shell: Pendulum designed and ran its own randomised controlled trial and published it in a peer-reviewed journal.
Its central product is Akkermansia muciniphila, a gut bacterium that has attracted genuine scientific interest for its association with metabolic health. Pendulum describes its version as 'the only live Akkermansia probiotic', at 100 million AFU per capsule, from $54 a month on subscription or $75 one-time.
Around that sit Metabolic Daily at $49 a month, a GLP-1 Probiotic at $64, Glucose Control at $99 to $267 depending on plan, a Polyphenol Booster from $25 and a Gut Fuel prebiotic fibre from $12. Multi-month plans and autoship sets run considerably higher — a Glucose Control Pro autoship set is listed at $900.
Two notes on measurement and naming before the evidence. Pendulum uses AFU — Active Fluorescent Units — rather than the CFU count most probiotics quote. That is a legitimate choice for strict anaerobes like Akkermansia, which do not form colonies on a plate the way conventional probiotic organisms do, but it means the number is not directly comparable to a CFU figure on another brand's label.
And the GLP-1 Probiotic name deserves care. Pendulum describes GLP-1 as 'the un-hunger hormone' and says the product is 'formulated with the strains that help you produce more of it'. It is a probiotic, not a GLP-1 medication, and produces nothing remotely comparable to semaglutide. We have a separate detailed review of that specific product, linked below.
Manufacturer
Pendulum Therapeutics, Inc., 933 20th Street, San Francisco, California, trading since 2 January 2013, BBB accredited since 13 May 2022 with an A+ rating. The company employs its own research scientists and has published clinical work in peer-reviewed journals. Its BBB complaint record includes a shipping concern directly relevant to a live-organism product — a customer describing an order that 'arrived early and left in a hot metal mailbox in the sun' with 'no insulated packaging', shipped 'in a thin bubble envelope' — and a fulfilment complaint from a customer charged for an order never received despite six contacts with support.
Intended use
Pendulum sells these as dietary supplements for gut health, metabolic support, blood sugar management and appetite regulation. They are not medicines. None is FDA-approved to treat any condition, and none is a substitute for diabetes medication or a GLP-1 drug.
Ingredients & Amounts
| Ingredient | Amount | Stated role |
|---|---|---|
| Akkermansia muciniphila | 100M AFU/capsule — $54/mo sub, $75 one-time | The flagship strain; described by Pendulum as the only live Akkermansia probiotic |
| Metabolic Daily | $49/mo sub · $69 one-time · $132 (3mo) · $264 (6mo) | Multi-strain metabolic formula |
| GLP-1 Probiotic | $64/mo · $173 (3mo) · $89 one-time | Akkermansia muciniphila, Clostridium butyricum, Bifidobacterium infantis |
| Glucose Control | $99–$267 · $139 one-time | Five strains plus inulin — the formula used in the published trial |
| — Akkermansia muciniphila | In Glucose Control | Mucin-degrading; associated with gut barrier integrity |
| — Clostridium butyricum | In Glucose Control | Butyrate producer |
| — Anaerobutyricum hallii | In Glucose Control | Butyrate producer |
| — Clostridium beijerinckii | In Glucose Control | Butyrate producer |
| — Bifidobacterium infantis | In Glucose Control | Oligosaccharide consumer |
| — Inulin | In Glucose Control | Prebiotic fibre |
| Polyphenol Booster | $25–$75 | |
| Gut Fuel | $12–$108 | Prebiotic fibre, packets or pouch |
| Glucose Control Pro Autoship Set | $900 | The most expensive item in the catalogue |
Pendulum names every strain in its formulas, which is the right way to sell a probiotic — strain identity is what determines whether any published research applies to the product in your hand. On price, this is a premium range and the multi-month commitments are large: $224 for six months of Akkermansia, $264 for six months of Metabolic Daily, $267 for Glucose Control and $900 for the Glucose Control Pro autoship set. Note also the gap between subscription and one-time pricing — Akkermansia is $54 on subscription against $75 one-off, a 28% difference, so the advertised price assumes recurring billing.
What the Manufacturer Claims
These are Pendulum Therapeutics, Inc.'s claims, quoted from its own marketing — not our findings.
- “The only live Akkermansia probiotic clinically shown to fortify the gut lining, reduce gut permeability, and support gut health. 100M AFU per capsule.
- “Glucose Control: clinically shown to reduce A1C levels and glucose spikes.
- “Reduces A1C by 0.6 percentage points; reduces post-meal glucose spikes by 32.5%.
- “GLP-1 is the 'un-hunger hormone' that supports a healthy weight, and this probiotic is formulated with the strains that help you produce more of it.
- “77% reported improved gut health and 82% reported more regular bowel movements over 3 months — based on a consumer survey.
Pendulum labels its consumer survey as a consumer survey rather than dressing it up as a study, which is more honest than most of this category. The claims that need scrutiny are the clinical ones, and they need it precisely because Pendulum has done the rare and creditable thing of running real trials — which means the results can be checked against the marketing. Two gaps emerge. 'Clinically shown to reduce A1C levels' rests on a result that did not reach statistical significance. And 'the only live Akkermansia probiotic' is true as stated, but the landmark human data on Akkermansia came from pasteurised bacteria, not live ones — a distinction that cuts against the product rather than for it, and which the marketing does not address.
What the Science Actually Supports
The Akkermansia research is genuinely interesting and worth understanding properly. The landmark human study is Depommier and colleagues, published in Nature Medicine in July 2019 — a randomised, double-blind, placebo-controlled pilot in overweight and obese insulin-resistant volunteers, 40 enrolled and 32 completing, taking 10 billion A. muciniphila daily, either live or pasteurised, for three months.
Its findings were meaningful but specific. Pasteurised A. muciniphila improved insulin sensitivity by 28.6% (P = 0.002), reduced insulinaemia by 34.1% (P = 0.006) and lowered total cholesterol by 8.7% (P = 0.02) against placebo. Those are real, statistically significant metabolic effects.
Two caveats matter enormously. First, the weight and body composition outcomes did not reach significance: body weight fell 2.27 kg (P = 0.091), fat mass 1.37 kg (P = 0.092) and hip circumference 2.63 cm (P = 0.091) — all above the conventional 0.05 threshold. This was not a weight-loss result. Second, and more directly relevant here, the significant improvements came from the pasteurised bacteria. Live A. muciniphila did not produce them. Pendulum sells live Akkermansia and markets it as a distinguishing feature.
Pendulum's own trial is Perraudeau and colleagues, published in BMJ Open Diabetes Research & Care on 27 July 2020. Twelve weeks, people with type 2 diabetes already taking metformin with or without a sulfonylurea, 23 randomised to the product and 26 to placebo — a small study, and all authors were Pendulum employees, which the paper disclosed.
Its results: glucose after a three-hour meal-tolerance test fell by 36.1 mg/dL (P = .05), and A1c fell by 0.6 percentage points (P = .054). The glucose result reached the conventional significance threshold. The A1c result did not. A 0.6 percentage point A1c reduction would be clinically meaningful if real — comparable to some oral diabetes medications — but P = .054 means the trial did not establish it.
More recent work has continued in this area, including a 2026 Nature Medicine randomised trial of pasteurised A. muciniphila for weight-loss maintenance, and studies suggesting the effect depends on how much Akkermansia you already have in your gut — with people starting low benefiting more. That is an active and legitimate research field, not a fringe one.
On the GLP-1 question specifically: certain gut bacteria and the short-chain fatty acids they produce, particularly butyrate, can stimulate endogenous GLP-1 secretion. That mechanism is real. The magnitude is nothing like a GLP-1 receptor agonist drug, and no trial has shown a probiotic producing weight loss comparable to semaglutide or tirzepatide.
Limits of That Evidence
- !The A1c claim is the one we would most want corrected. Pendulum's product page states Glucose Control is 'clinically shown to reduce A1C levels' and cites a 0.6 percentage point reduction. In the trial it cites, that result had a P value of .054 — narrowly missing the conventional 0.05 threshold for statistical significance. 'Clinically shown' is not an accurate description of a result the study did not establish. The glucose-spike finding at P = .05 is on firmer ground, and to be fair the trial was small at 49 participants, which makes marginal P values more likely. But a company sophisticated enough to run and publish a trial is sophisticated enough to describe it accurately.
- !The live-versus-pasteurised distinction cuts against the marketing. Depommier's significant improvements in insulin sensitivity, insulinaemia and cholesterol came from pasteurised A. muciniphila; live bacteria did not produce them in that trial. Pendulum markets 'the only live Akkermansia probiotic' as a selling point. It may be that live organisms confer other benefits — colonisation, mucin-layer effects — and Pendulum makes gut-lining claims rather than metabolic ones for Akkermansia alone. But anyone buying live Akkermansia because of the Nature Medicine metabolic findings should know those findings were not generated with live bacteria.
- !The trial population is narrower than the marketing audience. Perraudeau studied people with type 2 diabetes already taking metformin. That is a specific clinical group. It tells you little about what the product does for someone without diabetes taking it for weight management or general metabolic health, which is a large share of who will read this.
- !The published trial was conducted and authored entirely by Pendulum employees. That is disclosed, it is common in this field, and it does not invalidate the work — but company-run studies of company products warrant more caution than independent replication, and independent replication is what would settle this.
- !AFU is not CFU. Pendulum's 100M AFU per capsule uses a different measurement standard from the CFU counts on conventional probiotics. It is a defensible choice for strict anaerobes, but do not compare the number directly against another brand's CFU figure — they are not measuring the same thing.
- !Live probiotics are heat-sensitive, and a BBB complainant describes an order arriving 'in a thin bubble envelope' with 'no insulated packaging', left 'in a hot metal mailbox in the sun'. For a live-organism product sold at a premium on the basis of viability, shipping without temperature protection is a genuine product-integrity concern rather than a customer service quibble.
- !Pricing is high and the commitments are large. Six months of Akkermansia is $224, six months of Metabolic Daily $264, and a Glucose Control Pro autoship set $900. The advertised monthly prices assume a subscription — Akkermansia is 28% more as a one-off.
- !None of these products is FDA-approved, and none treats or manages any condition. If you have type 2 diabetes, this is not a substitute for your medication, and changes to blood sugar management belong with your clinician.
Directions, Warnings & Allergens
- Directions
- Follow the label for the specific product. Probiotics generally need consistent daily use over weeks before any effect would be expected, so a one-month trial is unlikely to tell you much — which is the honest argument for the three-month plans, and also why the cost adds up. Store as directed; these are live organisms and heat degrades them.
- Allergens
- Not comprehensively detailed on the pages we reviewed. Glucose Control contains inulin, a prebiotic fibre and known FODMAP that troubles many people with IBS. Check individual product panels for other ingredients.
Warnings
- ⚠These are supplements, not medicines. If you have type 2 diabetes, do not reduce or stop any prescribed medication on the basis of a probiotic. Any change to diabetes treatment belongs with your prescriber.
- ⚠If you are taking a GLP-1 medication, tell your clinician before adding a product marketed around GLP-1. It is very unlikely to cause a problem, but they should have the full picture.
- ⚠Anyone who is immunocompromised, has a central venous catheter, has recently had major surgery, or has a serious underlying illness should speak to a clinician before taking any live probiotic — there are documented cases of probiotic-associated infection in these groups.
- ⚠People with short bowel syndrome or significant gastrointestinal disease should seek medical advice before starting a live probiotic.
- ⚠Some people experience bloating, gas or changes in bowel habit when starting a probiotic; this typically settles.
- ⚠Prebiotic fibre products such as Gut Fuel and the inulin in Glucose Control can cause significant bloating and wind, particularly in people with IBS, where inulin is a known FODMAP trigger.
- ⚠Do not use in pregnancy or while breastfeeding without clinician advice.
- ⚠If your product arrives warm or has been left in the sun, contact the company — live organisms degrade with heat, and you may not be getting what you paid for.
- ⚠None of these products treats, cures or prevents any disease.
Pricing, Subscription, Refunds & Shipping
- Gut Fuel
- $12–$108
- Polyphenol Booster
- $25–$75
- Metabolic Daily
- $49/mo sub · $69 one-time · $264 for 6 months
- Akkermansia
- $54/mo sub · $75 one-time · $224 for 6 months
- GLP-1 Probiotic
- $64/mo · $89 one-time · $173 for 3 months
- Glucose Control
- $99–$267 · $139 one-time
- Glucose Control Pro Autoship Set
- $900
- Akkermansia Autoship Set
- $421.08
- Subscription discount
- Around 28% against one-time pricing
- Subscription
- Subscriptions are central to the pricing: the advertised monthly figures assume recurring billing, and one-time purchases cost roughly 28% more. Multi-month plans and autoship sets run to $224, $264, $421 and $900. Given that probiotics need weeks of consistent use before any effect would be expected, a longer commitment is more defensible here than in most categories — but establish the cancellation terms before committing to a $900 set.
- Refund policy
- We did not locate detailed refund terms on the pages we reviewed. Pendulum is BBB accredited with an A+ rating, which is at least consistent with reasonable handling, but its complaint file includes a customer charged for an order never received despite six contacts with support. Establish the refund and cancellation position in writing before starting a multi-month plan.
- Shipping
- Standard shipping. Note the complaint describing delivery 'in a thin bubble envelope' with 'no insulated packaging', left in a hot mailbox — for a live-organism product this matters. If you order in summer, consider timing delivery for when you can collect it promptly, and contact the company if it arrives warm.
Pros & Cons
Pros
- ✓Has designed, run and published its own randomised placebo-controlled trial in a peer-reviewed medical journal — almost unheard of in supplements
- ✓Names every strain in every formula, which is what determines whether research applies
- ✓Built on a genuinely active and legitimate area of microbiome science
- ✓BBB accredited since May 2022 with an A+ rating; trading since January 2013
- ✓Labels its consumer survey as a survey rather than presenting it as a study
- ✓Uses AFU measurement appropriately for strict anaerobes
- ✓Subscription pricing around 28% below one-time
- ✓Cheaper entry points available — Gut Fuel from $12, Polyphenol Booster from $25
- ✓Separately states that its GLP-1 Probiotic is not a GLP-1 agonist drug
- ✓Employs its own research scientists rather than licensing a white-label formula
Cons
- ✗Markets Glucose Control as 'clinically shown to reduce A1C' on a result with P = .054 — not significant
- ✗Sells live Akkermansia while the landmark metabolic findings used pasteurised bacteria
- ✗Its published trial was small (49 participants) and authored entirely by company employees
- ✗The trial population was people with type 2 diabetes on metformin, not general consumers
- ✗Weight and fat-mass outcomes in the Nature Medicine study did not reach significance
- ✗Premium pricing with large commitments — $224, $264, $421 and a $900 autoship set
- ✗Advertised monthly prices assume a subscription; one-time costs about 28% more
- ✗A complaint describes live probiotics shipped in a thin bubble envelope with no insulation
- ✗A complaint describes being charged for an order never received after six support contacts
- ✗AFU counts are not comparable with the CFU figures on other brands
- ✗Inulin in Glucose Control is a FODMAP and can cause significant symptoms in IBS
- ✗No refund terms located
Who It May Be Best For
- •People with type 2 diabetes on metformin — the population its trial actually studied — after discussing it with their clinician
- •Anyone interested in the Akkermansia research who wants a product with named strains and published work behind it
- •Buyers who value a company that publishes trials over one that publishes testimonials
- •People willing to commit three months, since probiotics need consistent use before any effect
- •Anyone wanting to try the category cheaply first via Gut Fuel at $12 or the Polyphenol Booster at $25
Who Should Avoid It
- •You are immunocompromised, have a central venous catheter, or have serious underlying illness — speak to a clinician before any live probiotic
- •You have IBS and react to FODMAPs — the inulin in Glucose Control is a known trigger
- •You are expecting weight loss comparable to a GLP-1 medication; nothing here does that
- •You would reduce diabetes medication on the strength of it — do not
- •You are pregnant or breastfeeding, without clinician advice
- •You are price-sensitive; this is among the most expensive supplement ranges we have reviewed
- •You want independently replicated evidence rather than company-run trials
Alternatives
Our Pendulum GLP-1 Probiotic deep dive
A product-level review of the GLP-1 Probiotic specifically — its three strains, what Pendulum claims, and what it states plainly it will not do.
Read more →Probiotics and Metabolic Health
The wider evidence on gut bacteria and metabolism, without a product attached.
Read more →Best Probiotic Supplements for Weight Management
How Pendulum compares against the rest of the category on strains, evidence and price.
Read more →Frequently Asked Questions
Does Pendulum Glucose Control actually lower A1c?
The evidence is weaker than the marketing implies. Pendulum cites a 0.6 percentage point A1c reduction from its own trial — Perraudeau et al., BMJ Open Diabetes Research & Care, July 2020 — but that result had a P value of .054, narrowly missing the conventional threshold for statistical significance. The trial's glucose-spike finding did reach significance at P = .05. So describing the product as 'clinically shown to reduce A1C levels' overstates what the study established. The trial was also small, at 49 participants, and all its authors were Pendulum employees.
Is the Akkermansia research real?
Yes, and it is genuinely interesting. The landmark study is Depommier et al., Nature Medicine, July 2019 — a randomised, double-blind, placebo-controlled pilot in overweight and obese insulin-resistant volunteers. It found that pasteurised A. muciniphila improved insulin sensitivity by 28.6%, reduced insulinaemia by 34.1% and lowered total cholesterol by 8.7% against placebo, all statistically significant. Research in this area has continued, including a 2026 Nature Medicine trial on weight-loss maintenance.
Why does live versus pasteurized matter?
Because the significant results came from the pasteurised form. In the Depommier trial, participants took either live or pasteurised A. muciniphila, and it was the pasteurised bacteria that produced the improvements in insulin sensitivity, insulinaemia and cholesterol — live bacteria did not. Pendulum markets 'the only live Akkermansia probiotic' as a distinguishing feature. Live organisms may confer other benefits, and Pendulum's Akkermansia claims are about gut lining rather than metabolism — but if the Nature Medicine metabolic findings are why you are buying, know that those findings were not generated with live bacteria.
Will this help me lose weight?
Do not buy it expecting that. In the Depommier trial the weight and body composition outcomes did not reach statistical significance — body weight fell 2.27 kg at P = 0.091, fat mass 1.37 kg at P = 0.092. Those are the numbers people quote, and they are the ones the study did not establish. No probiotic produces weight loss remotely comparable to a GLP-1 medication.
Is the GLP-1 Probiotic like taking Ozempic?
No, and it is nothing like it. Certain gut bacteria and the butyrate they produce can stimulate your body's own GLP-1 secretion — that mechanism is real — but the magnitude is nowhere near a GLP-1 receptor agonist drug. Pendulum itself states elsewhere that the product is not a GLP-1 agonist and is not intended for weight loss. We have a separate detailed review of that specific product.
What is AFU and why not CFU?
AFU stands for Active Fluorescent Units, and Pendulum uses it because Akkermansia is a strict anaerobe that does not form colonies on a plate the way conventional probiotic organisms do — so the standard CFU counting method does not work. It is a legitimate choice. The practical consequence is that Pendulum's 100M AFU per capsule cannot be compared directly against another brand's CFU number; they measure different things.
Is Pendulum a legitimate company?
Yes, and among the most credible in this review series. Pendulum Therapeutics, Inc. has traded from San Francisco since January 2013, is BBB accredited — since May 2022 — with an A+ rating, employs its own research scientists, and has published clinical work in peer-reviewed journals. Our criticisms are about how precisely it describes its own results, not about whether the science or the company is real.
Will it arrive in good condition?
Worth thinking about if you order in summer. These are live organisms and heat degrades them. A BBB complainant describes an order arriving 'in a thin bubble envelope' with 'no insulated packaging', left 'in a hot metal mailbox in the sun'. For a premium product sold on viability, that is a real concern — time delivery for when you can collect promptly, and contact the company if it arrives warm.
Is it worth the money?
It is expensive: $54 a month for Akkermansia on subscription, $49 for Metabolic Daily, $99 and up for Glucose Control, and autoship sets to $900. Whether that is justified depends on who you are. If you have type 2 diabetes on metformin — the population its trial studied — and your clinician is comfortable, there is at least relevant evidence, imperfect though it is. If you are buying for general weight management, the evidence does not support the expectation. Start with a cheaper entry point and give it three months, because probiotics need consistent use before anything would show.
Our Take
Pendulum is the most scientifically serious company in this entire review series, and that should be said before anything else. It has traded since 2013, is BBB accredited with an A+ rating, employs its own research scientists, names every strain in every formula, and — almost uniquely for a supplement brand — designed, ran and published a randomised placebo-controlled trial in a peer-reviewed medical journal. The Akkermansia field it is built on is a legitimate and active area of microbiome science, not a marketing invention.
Which is exactly why the marketing gaps matter. Pendulum describes Glucose Control as 'clinically shown to reduce A1C levels' and quotes a 0.6 percentage point reduction. In its own cited trial, that A1c result had a P value of .054 — it did not reach statistical significance. The glucose-spike result did, at P = .05. A company capable of running a trial is capable of describing it accurately, and 'clinically shown' is not an accurate description of a finding the study failed to establish.
The second gap concerns the flagship product. The landmark Akkermansia findings — insulin sensitivity up 28.6%, insulinaemia down 34.1%, cholesterol down 8.7%, all significant — came from pasteurised bacteria in Depommier's 2019 Nature Medicine pilot. Live Akkermansia did not produce them. Pendulum sells live Akkermansia and markets that as a distinguishing feature. It may well be right that live organisms do something valuable, and its Akkermansia claims are about gut lining rather than metabolism — but a buyer drawn in by the metabolic research deserves to know it was not generated with the form they are buying.
Two smaller points. The weight and fat-mass outcomes in that same trial did not reach significance either, so nobody should buy this expecting weight loss. And a complaint describing live probiotics shipped in an uninsulated bubble envelope into a hot mailbox is a product-integrity issue for something sold on viability at $54 a month.
We rate Pendulum 4.0 out of 5 — real science, real trials, real credentials, described with less precision than the science deserves.
If you have type 2 diabetes on metformin, this is the one supplement in this series with directly relevant published evidence, and it is worth raising with your clinician — while being clear it does not replace your medication. If you are buying for weight loss, the evidence does not support the expectation. And whatever you buy, give it three months, because a month will tell you nothing.
Supplement disclaimer: These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Dietary supplements are not reviewed or approved by the FDA for safety or effectiveness before they are sold, and a supplement is not equivalent to, or a replacement for, prescription GLP-1 medication such as semaglutide or tirzepatide. We make no claim that any supplement will cause weight loss.
How we sourced this review: Ingredients, amounts, claims, pricing and policies above were taken from Pendulum Therapeutics, Inc.'s own published product page as of August 2026, and are quoted or attributed as such. Where the company does not publish a detail, we say so rather than estimate. Formulations and prices change — check the current label before buying.
Disclosure: This article may contain affiliate links, and CoreAge Rx is a paid sponsor of our supplement coverage. Sponsorship determines placement in our sponsored slots; it does not change the ingredient, claim, evidence or policy information we report, which comes from each manufacturer's own published material.